Neira I, Poblete L, Porcille P, Silva P, Araya J, Bórquez J, Morales G, Loyola L A, Sagua H
Unidad de Parasitología, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Chile.
Bol Chil Parasitol. 1998 Jan-Jun;53(1-2):9-13.
The trypanocidad activity against amastigote forms of SPA-14, Tulahuen and G strains and CL Brener clone of Trypanosoma cruzi of diterpenoids isolated from Azorella compacta, Phil. (Llareta), a plant with ethnomedicinal prestige from prespanish age, was investigated. Amastigocidal activity was shown in azorellanol (2), diterpene isolated by first time, with an inhibitory concentration 50 (IC50) that varied between 60 M (CL Brener clone) and 84 M (SPA-14 strain), and in mulin -11,13 -dien-20-oico acid (5) with IC50 between 41 microM (G strain) and 87 mM (CL Brener clone). The cytotoxicity levels of both compounds against Hela and Vero cells and macrophages J144 are lower than nifurtimox and similar to gentian violet.
对从阿索雷拉密丛草（Phil.（拉雷塔））中分离得到的二萜类化合物针对克氏锥虫的无鞭毛体形式的杀锥虫活性进行了研究，该植物自西班牙前时代起就具有民族药用声誉，涉及SPA - 14、图拉温菌株和G菌株以及CL Brener克隆。首次分离得到的二萜类化合物偶氮瑞香醇（2）表现出杀无鞭毛体活性，其半数抑制浓度（IC50）在60 μM（CL Brener克隆）至84 μM（SPA - 14菌株）之间变化；穆林-11,13-二烯-20-油酸（5）的IC50在41 μM（G菌株）至87 mM（CL Brener克隆）之间。这两种化合物对Hela细胞、Vero细胞和巨噬细胞J144的细胞毒性水平低于硝呋替莫，且与龙胆紫相似。
