Taniguchi T, Tanaka N, Taki S
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan.
Eur Cytokine Netw. 1998 Sep;9(3 Suppl):43-8.
Interferon regulatory factor-1 (IRF-1) is a transcriptional activator which was originally identified as the regulator of the type I interferon (IFN-alpha/beta) gene expression. Subsequent studies have revealed that IRF-1 is involved in a wide spectrum of the host defense mechanisms, including the antiviral response by IFNs. IRF-1 has also been shown to regulate a variety of cytokines and their target genes, thereby contributing to the development and function of the Th1-type immune response. Furthermore, IRF-1 is a critical regulator of cell growth and death, and its inactivation accelerates cell transformation. IRF-1 may be a prototypical example of a transcription factor which can selectively modulate distinct sets of genes depending on the cell type and/or nature of the cellular stimuli, so as to evoke appropriate response in each.
干扰素调节因子1（IRF-1）是一种转录激活因子，最初被鉴定为I型干扰素（IFN-α/β）基因表达的调节因子。随后的研究表明，IRF-1参与了广泛的宿主防御机制，包括IFN介导的抗病毒反应。IRF-1还被证明可调节多种细胞因子及其靶基因，从而促进Th1型免疫反应的发育和功能。此外，IRF-1是细胞生长和死亡的关键调节因子，其失活会加速细胞转化。IRF-1可能是转录因子的一个典型例子，它可以根据细胞类型和/或细胞刺激的性质选择性地调节不同的基因集，从而在每种情况下引发适当的反应。
