安乃近对实验性输尿管结石病大鼠的镇痛活性：中枢和外周成分
Antinociceptive activity of metamizol in rats with experimental ureteric calculosis: central and peripheral components.
作者信息
Laird J M, Roza C, Olivar T
机构信息
Dpto. Fisiología, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
出版信息
Inflamm Res. 1998 Oct;47(10):389-95. doi: 10.1007/s000110050349.
OBJECTIVE AND DESIGN
To study the antinociceptive effects of metamizol in a rat model of ureteric calculosis.
SUBJECTS
Adult female Wistar rats (n = 40).
TREATMENT
Metamizol was given i.p. 50-100 mg/kg, 3 times daily for 4 days for behavioural testing, and 25-100 mg/kg i.v. whilst recording peristalsis or dorsal horn neurons.
METHODS
An artificial stone was induced in one ureter. In 3 separate groups of stone-implanted rats, behaviour was recorded continuously on video tape, ureteric peristalsis or the electrical activity of single nociceptive dorsal horn neurons with ureteric input was recorded under anaesthesia. Data were compared with analysis of variance.
RESULTS
Metamizol inhibited the behavioural visceral crises, the abnormal ureteric peristalsis and the activity of nociceptive dorsal horn neurons.
CONCLUSIONS
Metamizol has central antinociceptive effects on the pain produced by a ureteric stone, and an additional spasmolytic effect on the hyperperistalsis produced by the stone.
目的与设计
研究安乃近在输尿管结石症大鼠模型中的抗伤害感受作用。
对象
成年雌性Wistar大鼠（n = 40）。
治疗
行为测试时，安乃近腹腔注射50 - 100 mg/kg，每日3次，共4天；记录蠕动或背角神经元时，静脉注射25 - 100 mg/kg。
方法
在一侧输尿管诱导形成人工结石。在3组分别植入结石的大鼠中，用录像带连续记录行为，在麻醉下记录输尿管蠕动或具有输尿管传入的单个伤害性背角神经元的电活动。数据采用方差分析进行比较。
结果
安乃近抑制行为性内脏危象、异常输尿管蠕动及伤害性背角神经元的活动。
结论
安乃近对输尿管结石所致疼痛具有中枢抗伤害感受作用，对结石所致的蠕动亢进还有额外的解痉作用。
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