Cohn-Cedermark G, Månsson-Brahme E, Rutqvist L E, Larsson O, Johansson H, Ringborg U
Department of Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Acta Oncol. 1998;37(5):463-70. doi: 10.1080/028418698430412.
The objectives of this population-based study were to assess putative prognostic factors for central nervous system (CNS) metastases among patients with cutaneous malignant melanoma, to assess the cumulative risk of CNS metastases in different subsets of patients with recurrent disease, and to describe patient outcome. At a median follow-up of 11 years, 201/2516 patients with melanoma had developed CNS metastases, corresponding to a cumulative risk at 5 years of 7%. In 41 of these 201 patients the CNS metastases were recorded as the first site of recurrence. In a Cox's multivariate model, primary tumor thickness and ulceration in stage I patients were independent risk factors. The cumulative rates of incidence of CNS metastases 5 years after local or regional recurrence as first event were 5 and 42%, respectively. These results may help to form an individually based risk assessment, which might be of value for melanoma patients in certain occupations.
这项基于人群的研究旨在评估皮肤恶性黑色素瘤患者发生中枢神经系统（CNS）转移的假定预后因素，评估不同复发疾病亚组患者发生CNS转移的累积风险，并描述患者的预后情况。在中位随访11年时，2516例黑色素瘤患者中有201例发生了CNS转移，5年累积风险为7%。在这201例患者中，有41例的CNS转移被记录为首个复发部位。在Cox多变量模型中，I期患者的原发肿瘤厚度和溃疡是独立的危险因素。首次事件为局部或区域复发后5年，CNS转移的累积发生率分别为5%和42%。这些结果可能有助于形成基于个体的风险评估，这对某些职业的黑色素瘤患者可能具有价值。
