Moga M M
Department of Anatomy, Indiana University School of Medicine, Terre Haute 47809, USA.
Neuroreport. 1998 Oct 5;9(14):3197-200. doi: 10.1097/00001756-199810050-00012.
The rat suprachiasmatic (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. In some SCN neurons, p75NTR is co-localized with vasoactive intestinal peptide (VIP). The present study examines the effect of third ventricle administration of 192 IgG-saporin immunotoxin on p75NTR and VIP immunoreactivity in the rat SCN. The 192 IgG-saporin immunotoxin abolished p75NTR immunoreactivity in the SCN. VIP immunoreactivity in the SCN of saporin-lesioned animals was not significantly different from that of control animals. Immunolesions of the p75NTR-ir cell population in the SCN may prove useful in clarifying the role of p75NTR in circadian timing.
大鼠视交叉上核（SCN）含有密集的低亲和力p75神经营养因子受体（p75NTR）免疫反应性神经丛。在一些SCN神经元中，p75NTR与血管活性肠肽（VIP）共定位。本研究检测了经第三脑室注射192 IgG-皂草素免疫毒素对大鼠SCN中p75NTR和VIP免疫反应性的影响。192 IgG-皂草素免疫毒素消除了SCN中的p75NTR免疫反应性。经皂草素损伤的动物SCN中的VIP免疫反应性与对照动物的无显著差异。对SCN中p75NTR免疫反应性细胞群进行免疫损伤可能有助于阐明p75NTR在昼夜节律中的作用。
