Moga M M
Department of Anatomy, Indiana University School of Medicine, Terre Haute 47809-9989, USA.
Neurosci Lett. 1998 Sep 11;253(3):187-90. doi: 10.1016/s0304-3940(98)00658-2.
The rat suprachiasmatic nucleus (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. Scattered patches of p75NTR immunoreactivity are present in the intergeniculate leaflet (IGL). Both SCN and IGL receive a direct retinal input. After binocular enucleation, there is a delayed loss of p75NTR-immunoreactivity in the SCN and IGL beginning at, respectively, 4 and 8 weeks post-enucleation, with complete loss occurring in both nuclei by week 12. This delayed loss may be due to an up-regulation of growth factor secretion by local cells in response to retinal axon degeneration.
大鼠视交叉上核（SCN）含有密集的低亲和力p75神经营养因子受体（p75NTR）免疫反应性神经丛。在间膝叶（IGL）中存在散在的p75NTR免疫反应性斑块。SCN和IGL均接受直接的视网膜输入。双眼摘除后，SCN和IGL中p75NTR免疫反应性分别在摘除后4周和8周开始延迟丧失，到第12周时两个核中均完全丧失。这种延迟丧失可能是由于局部细胞响应视网膜轴突变性而使生长因子分泌上调所致。
