Yonenaga F, Takasaki T, Ohi Y, Sagara Y, Akiba S, Yoshinaka H, Aikou T, Miyadera K, Akiyama S, Yoshida H
Department of Pathology I, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Japan.
Pathol Int. 1998 Nov;48(11):850-6. doi: 10.1111/j.1440-1827.1998.tb03851.x.
It has been shown that human thymidine phosphorylase (TP) is identical to platelet-derived endothelial cell growth factor and has angiogenic activity. In the present study, the expression of TP was examined in 139 mammary carcinomas and 35 benign mammary disorders using biochemical and immunohistochemical methods. Moreover, in order to evaluate the significance of TP expression in mammary carcinomas, the relationship between vascular density and various clinicopathological factors, including age and menopausal status of patients with a mammary carcinoma, were compared with the size, nodal status, expression of estrogen receptor (ER), progesterone receptor (PgR), c-erbB-2, p53 and TP of a mammary carcinoma. Thymidine phosphorylase expression increased in both the nuclei and cytoplasm of mammary carcinoma cells in comparison to mammary benign disorder cells. The number of microvessels in mammary carcinomas was generally correlated to the number of tumor cells with TP expression in cytoplasm. The number of cells with TP expression in cytoplasm was significantly large in tumors that measured 3-4 cm in diameter, compared with tumors measuring 1-2 and 5-6 cm in diameter. In mammary tumors of 1-4 cm diameter, TP expression and vessel density were significantly high in tumors negative for ER or positive for c-erbB2 and in tumors positive for TP or c-erbB2, respectively; whereas tumors of 5-6 cm in diameter were not modified by any clinicopathological factors. The results indicated that TP plays an important angiogenetic role in mammary carcinomas, especially tumors with a certain progression.
已表明人胸苷磷酸化酶（TP）与血小板衍生的内皮细胞生长因子相同，并具有血管生成活性。在本研究中，采用生化和免疫组化方法检测了139例乳腺癌和35例乳腺良性疾病中TP的表达。此外，为了评估TP表达在乳腺癌中的意义，将血管密度与各种临床病理因素之间的关系进行了比较，这些因素包括乳腺癌患者的年龄和绝经状态，以及乳腺癌的大小、淋巴结状态、雌激素受体（ER）、孕激素受体（PgR）、c-erbB-2、p53和TP的表达。与乳腺良性疾病细胞相比，乳腺癌细胞的细胞核和细胞质中胸苷磷酸化酶表达均增加。乳腺癌中的微血管数量通常与细胞质中表达TP的肿瘤细胞数量相关。与直径为1-2 cm和5-6 cm的肿瘤相比，直径为3-4 cm的肿瘤中细胞质中表达TP的细胞数量明显更多。在直径为1-4 cm的乳腺肿瘤中，ER阴性或c-erbB2阳性的肿瘤以及TP阳性或c-erbB2阳性的肿瘤中，TP表达和血管密度分别显著升高；而直径为5-6 cm的肿瘤则不受任何临床病理因素的影响。结果表明，TP在乳腺癌尤其是具有一定进展的肿瘤中发挥重要的血管生成作用。
