Faggiano P, D'Aloia A, Gualeni A, Ambrosino N, Pagani M, Giordano A
Cardiology Division of S. Orsola Hospital, Brescia, Italy.
Am J Cardiol. 1998 Nov 15;82(10):1296-8, A10. doi: 10.1016/s0002-9149(98)00622-5.
Short-term infusion of dobutamine may determine a mild, statistically significant increase in pulmonary artery pressure from baseline in 30% of patients with moderate to severe heart failure despite systemic effects (changes in cardiac index and systemic vascular resistance) similar to those observed in patients showing a large reduction in right heart pressures. The increase in pulmonary artery pressure observed seems to be associated with a lower pulmonary diffusing capacity, probably reflecting a reduction in recruitment and distension capacity of pulmonary circulation.
