Reist M, Marshall K A, Jenner P, Halliwell B
Neurodegenerative Disease Research Centre, Pharmacology Group, King's College, London, England.
J Neurochem. 1998 Dec;71(6):2431-8. doi: 10.1046/j.1471-4159.1998.71062431.x.
Sulphite is widely used as a preservative and antioxidant in foods, beverages, and pharmaceuticals. Endogenous sulphite is generated during the normal metabolism of sulphur-containing amino acids, and alterations in sulphur amino acid metabolism occur in some neurodegenerative diseases. In particular, sulphite oxidase deficiency produces severe mental retardation, seizures, spastic quadriparesis, dislocated lenses, and early death. Exposure of a neuronal cell line (rat mesencephalic cells) to high levels of sulphite induced a time-dependent decrease in viability. Peroxynitrite was also toxic to this cell line, and sulphite affected the toxicity of ONOO-. Sulphite concentrations of < or = 0.5 mM markedly potentiated cell damage induced by 200 microM ONOO-. We propose that sulphite can act as a neurotoxic agent, especially in combination with peroxynitrite. Sulphite radicals may be involved in the neurotoxic effect.
亚硫酸盐在食品、饮料和药品中被广泛用作防腐剂和抗氧化剂。内源性亚硫酸盐在含硫氨基酸的正常代谢过程中产生，并且在一些神经退行性疾病中会出现硫氨基酸代谢的改变。特别是，亚硫酸盐氧化酶缺乏会导致严重智力迟钝、癫痫发作、痉挛性四肢瘫、晶状体脱位和早亡。将一种神经细胞系（大鼠中脑细胞）暴露于高水平的亚硫酸盐中会导致其活力随时间下降。过氧亚硝酸盐对该细胞系也有毒性，并且亚硫酸盐会影响过氧亚硝酸盐的毒性。亚硫酸盐浓度≤0.5 mM时会显著增强由200 μM过氧亚硝酸盐诱导的细胞损伤。我们提出亚硫酸盐可能作为一种神经毒剂起作用，尤其是与过氧亚硝酸盐联合时。亚硫酸根自由基可能参与神经毒性作用。
