亚硫酸盐氧化酶表达在手术切除的肺腺癌中的临床病理意义
Clinicopathological significance of sulfite oxidase expression in surgically resected lung adenocarcinoma.
作者信息
Tokisawa Saeko, Kondo Reiichiro, Nakayama Masamichi, Ogasawara Sachiko, Murotani Kenta, Mitsuoka Masahiro, Hoshino Tomoaki, Yano Hirohisa, Akiba Jun
机构信息
Department of Pathology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
出版信息
Med Mol Morphol. 2024 Dec 9. doi: 10.1007/s00795-024-00413-z.
AIM
The coenzyme sulfite oxidase (SUOX), located in mitochondria, plays a role in redox and metabolism. Its expression has been associated with cancer progression and prognosis. Lung cancer has a high incidence rate and poor prognosis. We aim to clarify its expression in lung adenocarcinomas and investigated the utility of SUOX expression as a recurrence factor in operable lung adenocarcinoma.
METHODS
We used 60 formalin-fixed paraffin-embedded samples of operable primary lung adenocarcinoma between 2017 and 2018 to immunohistochemically assess SUOX expression levels. Patients were classified into a high or low SUOX expression group, and the associations of SUOX expression with clinicopathological findings and recurrence were analyzed.
RESULTS
We revealed that high SUOX expression was significantly (p < 0.05) associated with sex, low Brinkman index, histological type, histological grade and positive for epidermal growth factor receptor (EGFR) mutation. High SUOX expression (HR = 10.218, 95% CI 1.758‒59.376, p = 0.0096) and pathological Stage (HR = 7.538, 95% CI 1.95‒29.14, p = 0.0034) were independently associated with relapse free survival.
CONCLUSION
High SUOX expression may be a new indicator of recurrence risk in surgically resected lung adenocarcinomas.
目的
位于线粒体的辅酶亚硫酸盐氧化酶（SUOX）在氧化还原和代谢过程中发挥作用。其表达与癌症进展和预后相关。肺癌发病率高且预后差。我们旨在阐明其在肺腺癌中的表达情况，并研究SUOX表达作为可手术肺腺癌复发因素的效用。
方法
我们使用了2017年至2018年间60例可手术原发性肺腺癌的福尔马林固定石蜡包埋样本，通过免疫组织化学评估SUOX表达水平。将患者分为SUOX高表达组或低表达组，并分析SUOX表达与临床病理特征及复发之间的关联。
结果
我们发现SUOX高表达与性别、低布林克曼指数、组织学类型、组织学分级以及表皮生长因子受体（EGFR）突变阳性显著相关（p < 0.05）。SUOX高表达（HR = 10.218，95% CI 1.758 - 59.376，p = 0.0096）和病理分期（HR = 7.538，95% CI 1.95 - 29.14，p = 0.0034）与无复发生存独立相关。
结论
SUOX高表达可能是手术切除肺腺癌复发风险的一个新指标。
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