Tokisawa Saeko, Kondo Reiichiro, Nakayama Masamichi, Ogasawara Sachiko, Murotani Kenta, Mitsuoka Masahiro, Hoshino Tomoaki, Yano Hirohisa, Akiba Jun
Department of Pathology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Med Mol Morphol. 2024 Dec 9. doi: 10.1007/s00795-024-00413-z.
The coenzyme sulfite oxidase (SUOX), located in mitochondria, plays a role in redox and metabolism. Its expression has been associated with cancer progression and prognosis. Lung cancer has a high incidence rate and poor prognosis. We aim to clarify its expression in lung adenocarcinomas and investigated the utility of SUOX expression as a recurrence factor in operable lung adenocarcinoma.
We used 60 formalin-fixed paraffin-embedded samples of operable primary lung adenocarcinoma between 2017 and 2018 to immunohistochemically assess SUOX expression levels. Patients were classified into a high or low SUOX expression group, and the associations of SUOX expression with clinicopathological findings and recurrence were analyzed.
We revealed that high SUOX expression was significantly (p < 0.05) associated with sex, low Brinkman index, histological type, histological grade and positive for epidermal growth factor receptor (EGFR) mutation. High SUOX expression (HR = 10.218, 95% CI 1.758‒59.376, p = 0.0096) and pathological Stage (HR = 7.538, 95% CI 1.95‒29.14, p = 0.0034) were independently associated with relapse free survival.
High SUOX expression may be a new indicator of recurrence risk in surgically resected lung adenocarcinomas.
位于线粒体的辅酶亚硫酸盐氧化酶（SUOX）在氧化还原和代谢过程中发挥作用。其表达与癌症进展和预后相关。肺癌发病率高且预后差。我们旨在阐明其在肺腺癌中的表达情况，并研究SUOX表达作为可手术肺腺癌复发因素的效用。
我们使用了2017年至2018年间60例可手术原发性肺腺癌的福尔马林固定石蜡包埋样本，通过免疫组织化学评估SUOX表达水平。将患者分为SUOX高表达组或低表达组，并分析SUOX表达与临床病理特征及复发之间的关联。
我们发现SUOX高表达与性别、低布林克曼指数、组织学类型、组织学分级以及表皮生长因子受体（EGFR）突变阳性显著相关（p < 0.05）。SUOX高表达（HR = 10.218，95% CI 1.758 - 59.376，p = 0.0096）和病理分期（HR = 7.538，95% CI 1.95 - 29.14，p = 0.0034）与无复发生存独立相关。
SUOX高表达可能是手术切除肺腺癌复发风险的一个新指标。
