高血压患者亚组中膜镁离子浓度降低：原发性高血压发病机制的膜模型

Decreased membrane Mg2+ concentrations in a subgroup of hypertensives: membrane model for the pathogenesis of primary hypertension.

作者信息

Kisters K, Tepel M, Spieker C, Zidek W, Barenbrock M, Tokmak F, Kosch M, Hausberg M, Rahn K H

机构信息

Medical University Policlinic Department of Hypertension and Nephrology, University of Münster, Germany.

出版信息

Am J Hypertens. 1998 Nov;11(11 Pt 1):1390-3. doi: 10.1016/s0895-7061(98)00169-1.

DOI:10.1016/s0895-7061(98)00169-1

PMID:9832186

Abstract

Intracellular Mg2+ measurements were performed in erythrocyte membranes of 18 untreated normotensive and 19 untreated essential hypertensive patients. Mg2+ concentrations were determined by atomic absorption spectroscopy using a Video 12 apparatus. The results show that in patients with essential hypertension total Mg2+ content in erythrocyte membranes was significantly decreased as compared with the control group (0.28 +/-0.05 v 0.52+/-0.15 mmol/g membrane protein; mean+/-SD, P < .001). Additionally, plasma and free intracellular Mg2+ content of lymphocytes and platelets showed no significant difference in normotensives and hypertensives. Lowered total membrane Mg2+ concentrations in a subgroup of primary hypertensives may contribute to the development of this disorder, perhaps due to different buffering or membrane transport systems.

摘要

对18名未经治疗的血压正常患者和19名未经治疗的原发性高血压患者的红细胞膜进行了细胞内镁离子（Mg2+）测量。使用Video 12仪器通过原子吸收光谱法测定镁离子浓度。结果显示，与对照组相比，原发性高血压患者红细胞膜中的总镁离子含量显著降低（0.28±0.05对0.52±0.15 mmol/g膜蛋白；均值±标准差，P <.001）。此外，血压正常者和高血压患者的淋巴细胞和血小板的血浆及游离细胞内镁离子含量无显著差异。原发性高血压患者亚组中膜总镁离子浓度降低可能导致该疾病的发生，这可能是由于不同的缓冲或膜转运系统所致。