Chrysant Steven G, Chrysant George S
University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
INTEGRIS Baptist Medical Center, Oklahoma City, OK, USA.
Int J Cardiol Hypertens. 2019 Apr 23;1:100005. doi: 10.1016/j.ijchy.2019.100005. eCollection 2019 May.
The objective of this study was to review the current evidence on the effects of Mg deficiency on cardiovascular disease (CVD) and hypertension, since Mg is a potent vasodilator and modulates vasomotor tone, blood pressure and peripheral blood flow. Several factors could contribute to its deficiency and when it occurs, is associated with an increased incidence of cardiovascular disease (CVD), hypertension, heart failure (HF), and cardiac arrhythmias.
In order to get a better to get an updated perspective of the current status of Mg deficiency and its implications in CVD, hypertension, and cardiac arrhythmias, a focused Medline search of the English language literature was conducted between 2014 and 2018 and 30 pertinent papers were retrieved.
The analysis of data showed that Mg deficiency is difficult to occur, under normal circumstances, because it is plentiful in green leafy vegetables, cereals, nuts, and the drinking water. However, Mg deficiency can occur under special circumstances such as hypertension and HF treated with large doses of diuretics, patients with chronic kidney disease (CKD) treated with hemodialysis, and patients with gastroesophageal reflux disease treated with proton pump inhibitors. When hypomagnesemia occurs, it is associated with serious cardiac arrhythmias and aggravation of hypertension.
The analysis of data suggests that Mg deficiency doe occur and it is associated with an increased incidence of CVD, HF, serious cardiac arrhythmias, and hypertension. Retaining normal Mg levels will prevent the onset of these diseases.
本研究的目的是回顾目前关于镁缺乏对心血管疾病（CVD）和高血压影响的证据，因为镁是一种有效的血管扩张剂，可调节血管运动张力、血压和外周血流。有几个因素可能导致其缺乏，当缺乏发生时，与心血管疾病（CVD）、高血压、心力衰竭（HF）和心律失常的发病率增加有关。
为了更好地了解镁缺乏的现状及其在CVD、高血压和心律失常中的影响，于2014年至2018年对英文文献进行了重点Medline检索，共检索到30篇相关论文。
数据分析表明，在正常情况下，镁缺乏很难发生，因为绿叶蔬菜、谷物、坚果和饮用水中富含镁。然而，在特殊情况下可能会发生镁缺乏，如用大剂量利尿剂治疗的高血压和HF患者、接受血液透析治疗的慢性肾病（CKD）患者以及用质子泵抑制剂治疗的胃食管反流病患者。当发生低镁血症时，与严重心律失常和高血压加重有关。
数据分析表明镁缺乏确实存在，并且与CVD、HF、严重心律失常和高血压的发病率增加有关。维持正常的镁水平将预防这些疾病的发生。
