大鼠壁层胸膜中神经纤维与肥大细胞的相关性

Nerve fibers--mast cells correlation in the rat parietal pleura.

作者信息

Artico M, Iannetti G, Tranquilli Leali F M, Malinovsky L, Cavallotti C

机构信息

Faculty of Pharmacy, University of Rome La Sapienza, Italy.

出版信息

Respir Physiol. 1998 Aug;113(2):181-8. doi: 10.1016/s0034-5687(98)00053-x.

DOI:10.1016/s0034-5687(98)00053-x

PMID:9832236

Abstract

Our results show that a morphological correlation exists between catecholaminergic nerve fibers and mast cells in the rat parietal pleura. Mast cells are found in proximity to catecholaminergic nerve fibers. Moreover we have demonstrated that mast cells and nerve fibers in the perivascular areas of rat parietal pleura show the same formaldehyde fluorescence. In rats previously sympathectomized with neurotoxin 6-OHDA the nerve fibers appear disarranged and poorly fluorescent and related mast cells show a low fluorescence. The importance of this correlation and the possible role of mast cells are discussed.

摘要

我们的研究结果表明，大鼠壁层胸膜中儿茶酚胺能神经纤维与肥大细胞之间存在形态学上的相关性。肥大细胞位于儿茶酚胺能神经纤维附近。此外，我们还证明，大鼠壁层胸膜血管周围区域的肥大细胞和神经纤维呈现相同的甲醛荧光。在用神经毒素6-羟基多巴胺预先进行交感神经切除术的大鼠中，神经纤维排列紊乱且荧光较弱，相关的肥大细胞荧光也较低。本文讨论了这种相关性的重要性以及肥大细胞可能发挥的作用。