King A, Wilson H, Penney C, Michael W
Department of Neuropathology, Institute of Psychiatry, London, England, UK.
Clin Neuropathol. 1998 Nov-Dec;17(6):326-9.
Primary leptomeningeal lymphomas are rare, and usually follow a rapid clinical course with early systemic involvement. A 60-year-old woman presented with a 3-year history of worsening seizures and memory loss. Neuroimaging showed widespread meningeal calcification. After extensive investigations a meningeal biopsy revealed a low-grade B-cell lymphoma categorized as an extranodal marginal zone B-cell lymphoma, attributed to the same histological group as the MALT (mucosa-associated lymphoid tissue) lymphomas described in the stomach, thyroid, salivary glands and orbit. There was no evidence of systemic involvement. The extensive meningeal calcification would appear to be a novel finding in primary leptomeningeal lymphoma whereas the unusually long clinical history in this case is possibly related to the particular histological type of low-grade B-cell lymphoma.
原发性软脑膜淋巴瘤很罕见，通常临床病程进展迅速，早期即出现全身受累。一名60岁女性，有3年癫痫发作加重和记忆力减退病史。神经影像学检查显示广泛的脑膜钙化。经过广泛检查，脑膜活检显示为低级别B细胞淋巴瘤，分类为结外边缘区B细胞淋巴瘤，与胃、甲状腺、唾液腺和眼眶中描述的MALT（黏膜相关淋巴组织）淋巴瘤属于同一组织学类型。无全身受累证据。广泛的脑膜钙化在原发性软脑膜淋巴瘤中似乎是一个新发现，而该病例异常长的临床病史可能与低级别B细胞淋巴瘤的特定组织学类型有关。
