The effects of incentive on antisaccades: is a dopaminergic mechanism involved?

The effect of incentive was investigated upon performance in the antisaccade (AS), memory saccade (MS) and reflexive saccade (RS) task, alone and following performance in tasks of a psychometric battery. Accuracy performance (correct saccades) in the AS and MS task is dependent on two prefrontal functions, the preservation of transient information across short time intervals and the inhibition of prepotent but inappropriate responses, and is impaired in patient populations with known prefrontal dysfunction. It was predicted that, in normal humans, incentive will improve accuracy performance in the AS and MS task, leaving performance in the RS task unaffected (study 1). Saccades were recorded in 24 healthy young male volunteers. Measurements of saccades were performed (in the presence and absence of monetary incentive) alone or following performance on a psychometric test battery that included tasks of working memory, vigilance, attention and psychomotor activity. Incentive increased the number of correct saccades in the AS task and the performance index in the working memory task. No other direct changes were seen in the presence of incentive. The role of dopamine in performance in the AS compared to the RS task was investigated subsequently in study 2. Twenty healthy young male volunteers received levodopa and benserazide (100 and 25 mg, respectively) orally, and 1 and 5 h later measurements of AS and RS were performed. Levodopa significantly decreased the number of correct saccades in the AS task. No other effects were seen. These data, taken together, suggest, first, that the accuracy performance in the AS task is more sensitive than in the MS or RS task, to positive incentive due to monetary reward; and second, that the dopaminergic system may mediate such an effect, because levodopa, a dopaminergic drug, influenced the same performance measurement. The relationship, however, between these two manipulations (incentive and administration of dopaminergic drugs) is not clear, because incentive improved and levodopa impaired performance.