Kim S J, Bae S N, Kim J H, Kim C J, Han K T, Chung J K, Lee J M
Korean Research Institute of Gestational Trophoblastic Disease, Dept. of Obstetric and Gynecology, Catholic University School of Medicine, Seoul.
Int J Gynaecol Obstet. 1998 Apr;60 Suppl 1:S33-8.
For the purpose of determining the annual incidence and time trends of gestational trophoblastic disease (GTD), the medical records from 24 university hospitals, 13 private general hospitals and the Korean Research Institute of Gestational Trophoblastic Disease (KRI-TRD) were analyzed from 1971 to 1995.
MATERIALS & RESULTS: From a total of 7198 GTD cases (H-mole=3831, Invasive mole=2163, Choriocarcinoma=1177, PSTr=27) among 838659 deliveries between 1971 and 1995, the hospital-based incidence of H-mole per 1000 deliveries declined from 40.2 during 1971-975, to 2.3 during 1991-995. The population-based incidence of H-mole, however, revealed an average of 2.05 per 1000 deliveries during 1991-995. Old age and gravidities as factors in GTD patients both decreased significantly during the study period. Time trends for the incidence of GTD in Korea revealed significant changes, not only a decrease in the incidence of GTD, but also an improvement in the annual remission rate. Korea's socio-eonomic improvement in recent decades also contributed to the decreased incidence of GTD and the increased survival rates.
为了确定妊娠滋养细胞疾病（GTD）的年发病率和时间趋势，对1971年至1995年期间24所大学医院、13所私立综合医院以及韩国妊娠滋养细胞疾病研究所（KRI-TRD）的病历进行了分析。
在1971年至1995年期间的838659例分娩中，共有7198例GTD病例（葡萄胎=3831例、侵蚀性葡萄胎=2163例、绒毛膜癌=1177例、胎盘部位滋养细胞肿瘤=27例），以医院为基础的每1000例分娩中葡萄胎的发病率从1971 - 1975年期间的40.2降至1991 - 1995年期间的2.3。然而，以人群为基础的葡萄胎发病率在1991 - 1995年期间显示平均每1000例分娩中有2.05例。在研究期间，年龄较大和妊娠次数作为GTD患者的因素均显著下降。韩国GTD发病率的时间趋势显示出显著变化，不仅GTD发病率下降，而且年缓解率有所提高。近几十年来韩国社会经济的改善也导致了GTD发病率的下降和生存率的提高。
