Charitos C E, Nanas J N, Kontoyiannis D A, Nanas S N, Stamatopoulos G Z, Rapti A C, Stamatelopoulos S F, Moulopoulos S D
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, School of Medicine, Greece.
J Cardiovasc Surg (Torino). 1998 Oct;39(5):625-32.
The objective of the present study was to identify the hemodynamic variables, that preclude the effectiveness of the counterpulsation technique.
In order to achieve high counterpulsation volume two devices were used simultaneously. The para-aortic counterpulsation device pumping 60-70 ml was implanted on the ascending aorta, and the intra-aortic balloon (20 ml) was placed in the descending aorta of 14 dogs with severe cardiogenic shock. Both devices were synchronized to provide aortic diastolic augmentation. The mechanical assistance provided by these devices was considered adequate when the mean aortic pressure during the supportive period was at least 50 mmHg, a pressure compatible with life.
The mechanical assistance provided by the two devices was adequate in none (0%) of the cases with a systolic aortic pressure below 30 mmHg (Group I), in 71% of the cases with a systolic aortic pressure between 30-56 mmHg (Group II), and in 100% of the cases with a systolic aortic pressure above 56 mmHg (Group III). In group II the left ventricular end-diastolic pressure was higher in the cases responding adequately to mechanical assistance (Subgroup IIa) than in the ones where no adequate response was obtained (Subgroup IIb).
The very low levels of the systolic aortic pressure was the most important factor precluding the adequate effectiveness of the counterpulsation technique.
本研究的目的是确定妨碍反搏技术有效性的血流动力学变量。
为了实现高反搏容量,同时使用了两种装置。将泵血量为60 - 70毫升的主动脉旁反搏装置植入升主动脉,并将20毫升的主动脉内球囊置于14只严重心源性休克犬的降主动脉中。两种装置同步以提供主动脉舒张压增强。当支持期的平均主动脉压至少为50 mmHg(与生命相容的压力)时,这些装置提供的机械辅助被认为是足够的。
对于收缩期主动脉压低于30 mmHg的病例(I组),两种装置提供的机械辅助在无一例(0%)中足够;对于收缩期主动脉压在30 - 56 mmHg之间的病例(II组),71%足够;对于收缩期主动脉压高于56 mmHg的病例(III组),100%足够。在II组中,对机械辅助有充分反应的病例(IIa亚组)的左心室舒张末期压力高于未获得充分反应的病例(IIb亚组)。
收缩期主动脉压极低是妨碍反搏技术充分有效性的最重要因素。