Simonart T, Noel J C, Andrei G, Parent D, Van Vooren J P, Hermans P, Lunardi-Yskandar Y, Lambert C, Dieye T, Farber C M, Liesnard C, Snoeck R, Heenen M, Boelaert J R
Department of Dermatology, Hôpital Universitaire Erasme, Brussels, Belgium.
Int J Cancer. 1998 Dec 9;78(6):720-6. doi: 10.1002/(sici)1097-0215(19981209)78:6<720::aid-ijc9>3.0.co;2-f.
The role of iron in the pathogenesis of several tumours is being increasingly investigated. In particular, its involvement in the pathogenesis of Kaposi's sarcoma (KS) is suggested by the distribution of the endemic form of KS corresponding to continental rifts and associated iron-oxide-rich volcanic clays. We investigated in vitro to what extent iron supplementation or withdrawal could affect the growth of KS-derived cells, by analysing the effects of adding iron salts (iron chloride and ferric nitrilotriacetate) and/or reducing iron by iron chelators (desferrioxamine) on KS-derived cell cultures. The addition of iron salts strongly stimulated the growth of KS cells, as reflected by increase in thymidine incorporation and cell number. Conversely, desferrioxamine and deferiprone inhibited cell growth. The inhibitory effect of iron chelation was more pronounced on rapidly dividing basic fibroblast-growth-factor-stimulated cells. These results may point to a novel therapeutic approach to KS.
铁在几种肿瘤发病机制中的作用正受到越来越多的研究。特别是，卡波西肉瘤（KS）的地方性形式分布与大陆裂谷以及富含氧化铁的火山粘土相关，这表明铁参与了KS的发病机制。我们通过分析添加铁盐（氯化铁和次氮基三乙酸铁）和/或用铁螯合剂（去铁胺）减少铁对KS来源细胞培养物的影响，在体外研究了补充或去除铁在多大程度上会影响KS来源细胞的生长。添加铁盐强烈刺激了KS细胞的生长，这通过胸苷掺入量和细胞数量的增加得以体现。相反，去铁胺和地拉罗司抑制细胞生长。铁螯合的抑制作用在快速分裂的碱性成纤维细胞生长因子刺激的细胞上更为明显。这些结果可能指向一种治疗KS的新方法。
