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类固醇激素及绝经后激素替代疗法对女性乳房的生理影响及乳腺癌风险

Physiologic effects of steroid hormones and postmenopausal hormone replacement on the female breast and breast cancer risk.

作者信息

Mustafa I A, Bland K I

机构信息

Department of Surgery, Brown University School of Medicine, and Rhode Island Hospital, Providence 02903, USA.

出版信息

Ann Surg. 1998 Nov;228(5):638-51. doi: 10.1097/00000658-199811000-00003.

DOI:10.1097/00000658-199811000-00003
PMID:9833802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1191569/
Abstract

Most data demonstrate that breast cancer is hormonally influenced. For the woman with no history of breast cancer, the benefits of HRT may outweigh the risks. Although it remains the standard of care to discourage hormone use in patients who have had breast cancer, future studies may result in a change of this standard. There needs to be more research into these complex hormonal interactions so that we will have a better understanding of the true risks and benefits when we attempt to advise our patients regarding the best treatment regimens for them.

摘要

大多数数据表明乳腺癌受激素影响。对于没有乳腺癌病史的女性,激素替代疗法的益处可能超过风险。尽管对于患有乳腺癌的患者,不鼓励使用激素仍然是护理标准,但未来的研究可能会导致这一标准的改变。需要对这些复杂的激素相互作用进行更多研究,以便在我们试图就最佳治疗方案向患者提供建议时,能更好地了解真正的风险和益处。

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Physiologic effects of steroid hormones and postmenopausal hormone replacement on the female breast and breast cancer risk.类固醇激素及绝经后激素替代疗法对女性乳房的生理影响及乳腺癌风险
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Fortschr Geb Rontgenstr Nuklearmed. 1970 Oct;113(4):443-8.
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Environ Health Perspect. 2001 Mar;109 Suppl 1(Suppl 1):35-47. doi: 10.1289/ehp.01109s135.

本文引用的文献

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The relation of carcinoma of the breast and pregnancy in 283 patients.283例乳腺癌与妊娠的关系
Surg Gynecol Obstet. 1962 Jul;115:65-71.
2
Postmenopausal hormone therapy and mortality.绝经后激素治疗与死亡率
N Engl J Med. 1997 Jun 19;336(25):1769-75. doi: 10.1056/NEJM199706193362501.
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Patient-specific decisions about hormone replacement therapy in postmenopausal women.绝经后女性激素替代疗法的个体化决策。
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Induced abortion and the risk of breast cancer.人工流产与乳腺癌风险
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Postmenopausal estrogen and progestin use and the risk of cardiovascular disease.绝经后雌激素和孕激素的使用与心血管疾病风险
N Engl J Med. 1996 Aug 15;335(7):453-61. doi: 10.1056/NEJM199608153350701.
8
Hormones and breast cancer.激素与乳腺癌。
Cancer. 1995 Nov 15;76(10 Suppl):2059-63. doi: 10.1002/1097-0142(19951115)76:10+<2059::aid-cncr2820761325>3.0.co;2-1.
9
Younger women with breast carcinoma have a poorer prognosis than older women.患有乳腺癌的年轻女性比年长女性的预后更差。
Cancer. 1996 Jan 1;77(1):97-103. doi: 10.1002/(SICI)1097-0142(19960101)77:1<97::AID-CNCR16>3.0.CO;2-3.
10
Effect of estrogen replacement therapy on the specificity and sensitivity of screening mammography.雌激素替代疗法对乳腺钼靶筛查特异性和敏感性的影响。
J Natl Cancer Inst. 1996 May 15;88(10):643-9. doi: 10.1093/jnci/88.10.643.