Yang M S, Wong H F, Yung K L
Department of Biology, Hong Kong Baptist University, Kowloon Tong, SAR, PR China.
J Toxicol Environ Health A. 1998 Nov 27;55(6):445-53. doi: 10.1080/009841098158359.
Aluminum (Al) has been said to associate with the Alzheimer's-like neurodegeneration in humans. One of the proposed mechanisms for the action of Al is that excess Al might interfere with trace metal metabolism. In this study, the levels of Ca, Mg, Cu, and Zn in blood, liver, and different regions of the brain (separated into the cortex, hippocampus, cerebellum, and brainstem) were measured in mice after daily oral administration of AICI3 (100 mg/kg body weight) for 2 mo. It was found that upon prolonged oral administration of AI, serum Al level was elevated significantly. There was no marked change in serum Ca, Mg, Zn, or Cu content. In the liver, Al content was not increased but there was a significant elevation in Cu and Zn content compared to control animals, probably due to the prolonged administration of the acidic salt solution. In brain, there was a significant twofold increase in Al in the hippocampus and a significant decrease in Al in the cortex. In addition to regional changes in AI content, Zn content in the hippocampus and increased Cu content in the hippocampus, cortex, and brainstem were significantly reduced. Data demonstrated that Al could alter Zn and Cu homeostasis in selected brain regions. The possible relation between Al and neuronal cell injury was discussed.
铝（Al）据说与人类的阿尔茨海默氏症样神经退行性变有关。铝作用的一种推测机制是过量的铝可能会干扰微量金属代谢。在本研究中，对每日口服氯化铝（100毫克/千克体重）2个月后的小鼠，测量其血液、肝脏以及大脑不同区域（分为皮质、海马体、小脑和脑干）中的钙、镁、铜和锌水平。结果发现，长期口服铝后，血清铝水平显著升高。血清钙、镁、锌或铜含量没有明显变化。在肝脏中，铝含量没有增加，但与对照动物相比，铜和锌含量显著升高，这可能是由于长期给予酸性盐溶液所致。在大脑中，海马体中的铝含量显著增加了两倍，而皮质中的铝含量显著降低。除了铝含量的区域变化外，海马体中的锌含量以及海马体、皮质和脑干中增加的铜含量均显著降低。数据表明，铝可改变特定脑区的锌和铜稳态。讨论了铝与神经元细胞损伤之间的可能关系。
