UC-781在大鼠、兔子和猪的肠黏膜匀浆中的稳定性。 - Suppr

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超能文献

Stability of UC-781, in intestinal mucosal homogenates of the rat, rabbit, and pig.

作者信息

Van den Mooter G, Stas G, Damian F, Naesens L, Balzarini J, Kinget R, Augustijns P

机构信息

Laboratorium voor Farmacotechnologie en Biofarmacie, Katholieke Universiteit Leuven, Belgium.

出版信息

Pharm Res. 1998 Nov;15(11):1799-802. doi: 10.1023/a:1011985418360.

DOI:10.1023/a:1011985418360

PMID:9834007

Abstract

摘要

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Stability of UC-781, in intestinal mucosal homogenates of the rat, rabbit, and pig.UC-781在大鼠、兔子和猪的肠黏膜匀浆中的稳定性。

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Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus.新型硫代甲酰胺衍生物的鉴定，这些衍生物能以与野生型病毒相似的效力抑制多种耐药性突变的人类免疫缺陷病毒1型毒株。

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Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication.新型硫代羧酰苯胺戊烯氧基醚衍生物UC-781和UC-82作为1型人类免疫缺陷病毒复制抑制剂具有高度良好的抗病毒活性和耐药性特征。

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Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide.一系列与氧硫杂环戊烷甲酰苯胺相关的1型人类免疫缺陷病毒特异性化合物的构效关系及交叉耐药性评估

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