Herard A, Brasme L, Jaussaud R, Colin J, Vernet-Garnier V, Lardennois B
Service d'Urologie, CHU Robert Debré, Reims, France.
Prog Urol. 1998 Sep;8(4):579-85.
Coagulase-negative Staphylococci (CNS), considered for many years to be commensal bacteria of the skin are now recognized as major agents of nosocomial infection. Bacterial factors (increased resistance), host factors (immune status) and multiplication of the portals of entry (presence of foreign material) have contributed to the increased incidence of nosocomial infections. The importance of the role of NCS in urology is due to their great capacity to colonize catheters and most prostheses. The particular organization of these bacteria into a conglomerate called biofilm is responsible for prosthetic infections, which can impair renal function and can sometimes be life-threatening. The authors review the current increase of the number of CNS isolated in urology departments and describe the various therapeutic strategies that can be proposed to eradicate these bacteria.
凝固酶阴性葡萄球菌（CNS），多年来一直被认为是皮肤的共生菌，现在被公认为医院感染的主要病原体。细菌因素（耐药性增加）、宿主因素（免疫状态）以及侵入途径的增多（异物存在）导致了医院感染发病率的上升。凝固酶阴性葡萄球菌在泌尿外科中的重要作用归因于它们在导管和大多数假体上的强大定植能力。这些细菌聚集成称为生物膜的聚集体的特殊结构导致了假体感染，这可能损害肾功能，有时甚至危及生命。作者回顾了泌尿外科分离出的凝固酶阴性葡萄球菌数量目前的增加情况，并描述了可用于根除这些细菌的各种治疗策略。
