Lehéricy S, Hasboun D, Furet D, Dormont D, Deweer B, Baulac M, Dubois B, Marsault C
Service de Neuroradiologie, Bâtiment Babinski, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Rev Neurol (Paris). 1998;154 Suppl 2:S115-21.
Modern imaging techniques, and notably magnetic resonance imaging (MRI) enable an increasingly precise exploration of primary degenerative dementias. The main contribution of imaging is to demonstrate lesion localizations which confirm the degenerative nature of the observed disorders, contributing to an understanding of the correlation between clinical signs and causal lesions. The development of techniques quantifying cerebral volume which can be applied to an analysis of small structures such as the hippocampus coupled with a better understanding of primary degenerative dementias allow more specific study of the atrophy than could be obtained with a global assessment of ventricular dilatation. More recently, the development of MRI methods studying brain perfusion open the way for noninvasive exploration of perfusion anomalies in these patients.
现代成像技术，尤其是磁共振成像（MRI），能够对原发性退行性痴呆进行越来越精确的检测。成像的主要作用是显示病变定位，从而证实所观察到的疾病的退行性本质，有助于理解临床症状与病因性病变之间的相关性。能够用于分析海马体等小结构的脑容量量化技术的发展，再加上对原发性退行性痴呆的更好理解，使得对萎缩的研究比通过对脑室扩张的整体评估更具特异性。最近，研究脑灌注的MRI方法的发展为这些患者灌注异常的无创检测开辟了道路。
