Baron J C
Inserm U.320, Cyceron, Caen.
Rev Neurol (Paris). 1998;154 Suppl 2:S122-30.
In dementias and memory impairments of neurodegenerative origin, imaging of brain metabolism and perfusion by means of positron or single-photon emission tomography or functional MRI has utility in the following domains: 1) pathophysiology, by revealing the topography and severity of synaptic damage even at the earliest stages of the disease, at a time when structural imaging is of little or no help; 2) diagnosis, by showing profiles of abnormalities characteristic to each disorder, even though such profiles are neither specific to, nor constantly present in each disorder; 3) pharmacology, by providing a surrogate marker to evaluate objectively the effect of the drug being tested; and 4) neuropsychology, by mapping both the brain structures that underlie each subtype of memory impairment, and the reorganisation of large-scale networks that subserve task performance despite established synaptic lesions.
在神经退行性疾病所致的痴呆和记忆障碍中，通过正电子发射断层扫描、单光子发射计算机断层扫描或功能磁共振成像对脑代谢和灌注进行成像，在以下领域具有实用价值：1）病理生理学方面，即使在疾病的最早阶段，当结构成像作用甚微或毫无帮助时，也能揭示突触损伤的部位和严重程度；2）诊断方面，通过显示每种疾病特有的异常特征，尽管这些特征并非每种疾病所特有，也并非在每种疾病中都持续存在；3）药理学方面，提供一个替代指标以客观评估受试药物的效果；4）神经心理学方面，通过描绘构成每种记忆障碍亚型基础的脑结构，以及尽管存在已确定的突触病变但仍支持任务执行的大规模网络的重组情况。
