Tawara A, Tanaka T, Tsujioka K, Sudo Y, Ohnishi Y
Department of Ophthalmology, Wakayama Medical College, Japan.
Nippon Ganka Gakkai Zasshi. 1998 Oct;102(10):654-61.
We examined the effects of brovincamine fumarate, a Ca(2+)-channel blocker, on choroidal blood flow. We measured the choroidal blood volume continuously for 1 hour using laser Doppler flowmetry, as well as systemic blood pressure, heart rate, and intraocular pressure in six urethane-anesthetized rabbits after intravenous administration of 0.1 mg/kg or 0.5 mg/kg brovincamine. As a control, ten rabbits receiving no medication were used. All the data were recorded and analyzed using MacLab on a computer. In both the 0.1 mg/kg and 0.5 mg/kg brovincamine-injected groups, the choroidal blood volume decreased significantly after administration, but showed no significant difference from controls. Vascular resistance in the choroid showed a significant increase over the value before administration and over the control group. The heart rate decreased significantly compared to the value before injection and to the control group. The mean blood pressure in both dose groups and the intraocular pressure in the 0.5 mg/kg injected group were significantly higher than the controls. These results indicate that intravenous administration of 0.1 mg/kg or 0.5 mg/kg brovincamine does not cause an increase in the choroidal blood volume in urethane-anesthetized rabbits.
我们研究了钙通道阻滞剂富马酸溴长春胺对脉络膜血流的影响。我们使用激光多普勒血流仪，对6只经乌拉坦麻醉的兔子静脉注射0.1mg/kg或0.5mg/kg富马酸溴长春胺后，连续1小时测量脉络膜血容量，同时测量全身血压、心率和眼压。作为对照，使用了10只未接受药物治疗的兔子。所有数据均使用计算机上的MacLab进行记录和分析。在0.1mg/kg和0.5mg/kg富马酸溴长春胺注射组中，给药后脉络膜血容量均显著下降，但与对照组相比无显著差异。脉络膜血管阻力较给药前及对照组均显著增加。心率与注射前及对照组相比显著下降。两个剂量组的平均血压及0.5mg/kg注射组的眼压均显著高于对照组。这些结果表明，静脉注射0.1mg/kg或0.5mg/kg富马酸溴长春胺不会使乌拉坦麻醉兔子的脉络膜血容量增加。
