Weekers L, Scheen A J, Godon J P
Service de Néphrologie, Université de Liège.
Rev Med Liege. 1998 Sep;53(9):571-5.
The natural history of diabetic renal disease can be divided into different stages according to the degree of albuminuria and the level of glomerular filtration rate (GFR). Assessment of the early hyperfiltration state, as well as determination of the rate of decline in kidney function at a later stage require precise and accurate methods to measure GFR. In this article, we briefly remind the reader of the physiological basis of GFR. We then review the different techniques for the monitoring of kidney function (inulin clearance, endogenous creatinine clearance, plasma disappearance of a radiolabelled tracer) and discuss the pro and cons of each of them in different clinical settings. Finally, we try to define a rational use of these techniques in everyday clinical practice.
糖尿病肾病的自然病程可根据蛋白尿程度和肾小球滤过率（GFR）水平分为不同阶段。评估早期高滤过状态以及后期肾功能下降速率需要精确且准确的方法来测量GFR。在本文中，我们简要向读者介绍GFR的生理基础。然后，我们回顾监测肾功能的不同技术（菊粉清除率、内生肌酐清除率、放射性标记示踪剂的血浆消失率），并讨论它们在不同临床环境中的优缺点。最后，我们尝试确定这些技术在日常临床实践中的合理应用。
