Hankins C L, Strimling R, Rogers G S
Department of Surgery, Boston University School of Medicine, Massachusetts 02118, USA.
Dermatol Surg. 1998 Nov;24(11):1181-3. doi: 10.1111/j.1524-4725.1998.tb04095.x.
Botulinum A exotoxin injection is a well-established method for treatment of glabellar frown lines, crow's feet, and horizontal furrows of the forehead. However, there is no consensus as to the optimal dosage per injection site or the concentration of injectate to be used.
The purpose of this study was to determine the minimal effective dose per injection site to be used as well as the effect of concentration in response to treatment.
A total of 46 subjects were divided into ten groups and injected with escalating doses and concentrations of botulinum toxin. The response and longevity of treatment were then followed on a monthly basis. A dose between 2.5-4 U per injection site (12.5-20 U total) was determined to be an effective starting dose, with a duration of 2-5 months (median 14 weeks).
There was no statistically significant difference in safety or efficacy for concentrations ranging from 50 to 200 U/ml of botulinum toxin.
A型肉毒杆菌毒素注射是治疗眉间皱纹、鱼尾纹和前额水平皱纹的一种成熟方法。然而，关于每个注射部位的最佳剂量或所用注射剂的浓度尚无共识。
本研究的目的是确定每个注射部位的最小有效剂量以及浓度对治疗反应的影响。
总共46名受试者被分为十组，并注射递增剂量和浓度的肉毒杆菌毒素。然后每月跟踪治疗反应和持续时间。确定每个注射部位2.5 - 4单位（总计12.5 - 20单位）的剂量为有效起始剂量，持续时间为2 - 5个月（中位数14周）。
肉毒杆菌毒素浓度在50至200 U/ml范围内，安全性或有效性无统计学显著差异。
