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[急性嗜酸性粒细胞性肺炎。氯喹的可能作用]

[Acute eosinophilic pneumonia. Possible role of chloroquine].

作者信息

Coëtmeur D, Guivarch G, Briens E, Lopes C

机构信息

Service de Pneumologie, C. H. Saint-Brieuc.

出版信息

Rev Mal Respir. 1998 Oct;15(5):657-60.

PMID:9834994
Abstract

We report the case of a patient aged 49 who presented with a picture of an acute respiratory distress syndrome developing over several days after the preventative treatment of a burn using chloroquine (Nivaquine). The combination of clinical data, radiological and clinical as well as the broncho-alveolar lavage, enabled a diagnosis of acute eosinophilic pneumonia to be made according to Allen's criteria. The outcome after stopping the cloroquine and treating with corticosteroids was rapidly favourable and without any relapse. Based on this observation, we recall the characteristics of acute eosinophilic pneumonia as well as the causes which are currently established. Their potentially serious nature should encourage people to report similar cases to ours because even if we have not made identical observations to other cases. Chloroquine seems to us responsible for the clinical picture presented by our patient.

摘要

我们报告了一例49岁患者的病例,该患者在使用氯喹(磷酸氯喹)对烧伤进行预防性治疗几天后,出现了急性呼吸窘迫综合征的症状。结合临床数据、放射学和临床检查以及支气管肺泡灌洗结果,根据艾伦标准诊断为急性嗜酸性粒细胞性肺炎。停用氯喹并使用皮质类固醇治疗后,病情迅速好转且未复发。基于这一观察结果,我们回顾了急性嗜酸性粒细胞性肺炎的特征以及目前已明确的病因。其潜在的严重性应促使人们报告与我们病例相似的情况,因为即便我们尚未观察到与其他病例完全相同的情况。在我们看来,氯喹是导致该患者临床表现的原因。

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