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Non-peptidic corticotropin-releasing hormone receptor type 1 antagonist reverses restraint stress-induced shortening of sodium pentobarbital-induced sleeping time of rats: evidence that an increase in arousal induced by stress is mediated through CRH receptor type 1.

作者信息

Arai K, Ohata H, Shibasaki T

机构信息

Department of Physiology, Nippon Medical School, Tokyo, Japan. arai-keiko/

出版信息

Neurosci Lett. 1998 Oct 16;255(2):103-6. doi: 10.1016/s0304-3940(98)00719-8.

DOI:10.1016/s0304-3940(98)00719-8
PMID:9835225
Abstract

Stress shortens sodium pentobarbital (PbNa)-induced sleeping time through corticotropin-releasing hormone (CRH) in rats. We investigated whether this effect of brain CRH is mediated by CRH receptor type 1 (CRHR1) using a non-peptidic CRHR1 antagonist in rats. A 60 min period of restraint significantly shortened PbNa-induced sleeping time. This shortening was completely reversed by peripheral administration of CRHR1 antagonist. These results suggest that the stress-induced increase in arousal is mediated by CRHR1.

摘要

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