Björnhagen V, Månsson-Brahme E, Lindholm J, Mattsson A, Sørensen F B
Department of Plastic and Reconstructive Surgery, Karolinska Institute and Hospital, Stockholm, Sweden.
Melanoma Res. 1998 Oct;8(5):398-402. doi: 10.1097/00008390-199810000-00003.
Stereological estimation of nuclear volume was performed in a case control study of 72 malignant melanomas, thickness < or = 0.8 mm and Clark's level II-III. However, stereological measurements could be performed in only 57 thin melanomas due to too sparse cellularity. Thus, 21 thin metastasizing melanomas were individually compared with 33 thin non-metastasizing melanomas after individual matching of cases with one or two randomly chosen controls for site of primary tumour, tumour thickness, level of invasion, tumour regression and follow-up. Conditional logistic regression analysis showed no significant differences in nuclear volume between metastasizing and non-metastasizing thin malignant melanomas.
在一项针对72例恶性黑色素瘤的病例对照研究中，进行了核体积的体视学估计，这些黑色素瘤厚度≤0.8mm，且为克拉克分级II - III级。然而，由于细胞密度过低，仅对57例薄型黑色素瘤进行了体视学测量。因此，在根据原发肿瘤部位、肿瘤厚度、浸润程度、肿瘤消退情况及随访情况，将病例与一或两个随机选择的对照进行个体匹配后，对21例薄型转移性黑色素瘤与33例薄型非转移性黑色素瘤进行了个体比较。条件逻辑回归分析显示，转移性与非转移性薄型恶性黑色素瘤之间的核体积无显著差异。
