新型酮内酯HMR3647与大环内酯类和原始霉素对肠球菌属的体外活性比较
In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp.
作者信息
Torres C, Zarazaga M, Tenorio C, Portillo A, Saenz Y, Ruiz F, Baquero F
机构信息
Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3279-81. doi: 10.1128/AAC.42.12.3279.
Abstract
Ninety-four erythromycin-susceptible and 107 erythromycin-resistant enterococcal strains (MIC of >/=512 microgram/ml) were inhibited by the ketolide HMR3647 at MICs of </=0.007 to 0.06 and 0.03 to 8 microgram/ml, respectively. Eighteen vanA-positive isolates and 29 high-level-penicillin-resistant isolates, all of them erythromycin resistant, were inhibited by HMR3647 at an MIC range of 0.015 to 4 microgram/ml. The new ketolide has excellent activity against Enterococcus species.
摘要
94株对红霉素敏感和107株对红霉素耐药（最低抑菌浓度≥512微克/毫升）的肠球菌菌株分别被酮内酯HMR3647抑制，其最低抑菌浓度分别≤0.007至0.06微克/毫升和0.03至8微克/毫升。18株vanA阳性分离株和29株对青霉素高度耐药的分离株，所有这些菌株均对红霉素耐药，被HMR3647抑制，最低抑菌浓度范围为0.015至4微克/毫升。这种新型酮内酯对肠球菌具有优异的活性。
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