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In vitro activities of the novel ketolide telithromycin (HMR 3647) against erythromycin-resistant Streptococcus species.新型酮内酯类药物泰利霉素（HMR 3647）对耐红霉素链球菌的体外活性
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本文引用的文献

1
Antibacterial activity of RU 64004 (HMR 3004), a novel ketolide derivative active against respiratory pathogens.新型酮内酯衍生物RU 64004（HMR 3004）对呼吸道病原体的抗菌活性
Antimicrob Agents Chemother. 1997 Oct;41(10):2149-58. doi: 10.1128/AAC.41.10.2149.
2
Ketolides lack inducibility properties of MLS(B) resistance phenotype.酮内酯类药物缺乏MLS(B)耐药表型的诱导性。
J Antimicrob Chemother. 1997 Jul;40(1):85-90. doi: 10.1093/jac/40.1.85.
3
In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria.新型酮内酯类抗生素RU 64004对革兰氏阳性菌的体外活性
Antimicrob Agents Chemother. 1997 May;41(5):1196-202. doi: 10.1128/AAC.41.5.1196.
4
Antimicrobial activity of RU-66647, a new ketolide.新型酮内酯RU-66647的抗菌活性
Diagn Microbiol Infect Dis. 1997 Jan-Feb;27(1-2):7-12. doi: 10.1016/s0732-8893(96)00181-2.
5
In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004.新型酮内酯类抗菌剂RU-64004的体外评价
Antimicrob Agents Chemother. 1997 Feb;41(2):454-9. doi: 10.1128/AAC.41.2.454.
6
Emerging resistance to antimicrobial agents in gram-positive bacteria. Enterococci, staphylococci and nonpneumococcal streptococci.革兰氏阳性菌中对抗菌药物的新出现耐药性。肠球菌、葡萄球菌和非肺炎链球菌。
Drugs. 1996;51 Suppl 1:6-12. doi: 10.2165/00003495-199600511-00004.
7
Application of DNA probes for rRNA and vanA genes to investigation of a nosocomial cluster of vancomycin-resistant enterococci.将用于rRNA和vanA基因的DNA探针应用于耐万古霉素肠球菌医院聚集性感染的调查。
J Clin Microbiol. 1993 Mar;31(3):653-8. doi: 10.1128/jcm.31.3.653-658.1993.

新型酮内酯HMR3647与大环内酯类和原始霉素对肠球菌属的体外活性比较

In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp.

作者信息

Torres C, Zarazaga M, Tenorio C, Portillo A, Saenz Y, Ruiz F, Baquero F

机构信息

Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain.

出版信息

Antimicrob Agents Chemother. 1998 Dec;42(12):3279-81. doi: 10.1128/AAC.42.12.3279.

DOI:10.1128/AAC.42.12.3279
PMID:9835527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC106035/
Abstract

Ninety-four erythromycin-susceptible and 107 erythromycin-resistant enterococcal strains (MIC of >/=512 microgram/ml) were inhibited by the ketolide HMR3647 at MICs of </=0.007 to 0.06 and 0.03 to 8 microgram/ml, respectively. Eighteen vanA-positive isolates and 29 high-level-penicillin-resistant isolates, all of them erythromycin resistant, were inhibited by HMR3647 at an MIC range of 0.015 to 4 microgram/ml. The new ketolide has excellent activity against Enterococcus species.

摘要

94株对红霉素敏感和107株对红霉素耐药（最低抑菌浓度≥512微克/毫升）的肠球菌菌株分别被酮内酯HMR3647抑制，其最低抑菌浓度分别≤0.007至0.06微克/毫升和0.03至8微克/毫升。18株vanA阳性分离株和29株对青霉素高度耐药的分离株，所有这些菌株均对红霉素耐药，被HMR3647抑制，最低抑菌浓度范围为0.015至4微克/毫升。这种新型酮内酯对肠球菌具有优异的活性。