与红霉素、阿奇霉素、克拉霉素、罗红霉素及其他抗菌药物相比，泰利霉素（HMR 3647，RU 66647）对罕见厌氧菌的活性。
Activities of telithromycin (HMR 3647, RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and other antimicrobial agents against unusual anaerobes.
作者信息
Goldstein E J, Citron D M, Merriam C V, Warren Y, Tyrrell K
机构信息
The R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, USA.
出版信息
Antimicrob Agents Chemother. 1999 Nov;43(11):2801-5. doi: 10.1128/AAC.43.11.2801.
Abstract
The comparative activity of telithromycin (HMR 3647) against 419 human anaerobic isolates was determined by the agar dilution method. At concentrations of </=0.5 microgram/ml, telithromycin was active against Actinomyces israelii, Actinomyces odontolyticus, Bacteroides tectum, Bacteroides ureolyticus, Bacteroides gracilis (now Campylobacter gracilis), Porphyromonas spp. (including Porphyromonas gingivalis and Porphyromonas macacae), Prevotella intermedia, Prevotella heparinolytica, and almost all Peptostreptococcus species. Clostridia showed species and strain variability, often with a biphasic pattern. Fusobacterium species, except Fusobacterium russii, were relatively resistant.
摘要
采用琼脂稀释法测定了泰利霉素（HMR 3647）对419株人源厌氧菌的相对活性。在浓度≤0.5微克/毫升时，泰利霉素对以色列放线菌、溶齿放线菌、隐秘拟杆菌、解脲拟杆菌、纤细拟杆菌（现称纤细弯曲菌）、卟啉单胞菌属（包括牙龈卟啉单胞菌和猕猴卟啉单胞菌）、中间普雷沃菌、解肝素普雷沃菌以及几乎所有消化链球菌属菌种均有活性。梭菌属表现出种属和菌株差异，通常呈双相模式。除了拉氏梭杆菌外，梭杆菌属菌种相对耐药。
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