微小孢子虫兔脑炎微孢子虫、海伦脑炎微孢子虫和肠脑炎微孢子虫对阿苯达唑及其亚砜和砜代谢产物的体外敏感性。
In vitro susceptibilities of the microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to albendazole and its sulfoxide and sulfone metabolites.
作者信息
Ridoux O, Drancourt M
机构信息
Unité des Rickettsies CNRS UPRES-A 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille cedex 05, France.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3301-3. doi: 10.1128/AAC.42.12.3301.
Abstract
In vitro comparisons demonstrated that the efficacy of albendazole, albendazole-sulfoxide, and albendazole-sulfone against pathogenic Encephalitozoon species was proportional to the degree of oxidation at a concentration of >10(-3) microgram/ml. Furthermore, at a concentration of <10(-2) microgram/ml, benzimidazoles were more effective against Encephalitozoon cuniculi and Encephalitozoon hellem than against Encephalitozoon intestinalis.
摘要
体外比较表明，在浓度>10(-3)微克/毫升时，阿苯达唑、阿苯达唑亚砜和阿苯达唑砜对致病性脑胞内原虫属物种的疗效与氧化程度成正比。此外，在浓度<10(-2)微克/毫升时，苯并咪唑类药物对兔脑胞内原虫和海伦脑胞内原虫的作用比对肠脑胞内原虫更有效。
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