Franssen F F, Lumeij J T, van Knapen F
Department of Parasitology and Tropical Veterinary Medicine, University of Utrecht, The Netherlands.
Antimicrob Agents Chemother. 1995 Jun;39(6):1265-8. doi: 10.1128/AAC.39.6.1265.
In the light of the increased incidence of human Encephalitozoon infections and the absence of an established treatment protocol, a simple in vitro testing method to compare activities of drugs against Encephalitozoon cuniculi was developed. With this in vitro method, the 50% inhibitory concentrations of fumagillin, thiabendazole, albendazole, oxibendazole, and propamidine isethionate for E. cuniculi in rabbit kidney cells were determined. Itraconazole, toltrazuril, metronidazole, ronidazole, and ganciclovir were ineffective in this testing system.
鉴于人类脑胞内原虫感染的发生率增加且缺乏既定的治疗方案，开发了一种简单的体外检测方法来比较药物对兔脑胞内原虫的活性。通过这种体外方法，测定了烟曲霉素、噻苯达唑、阿苯达唑、奥昔苯达唑和乙磺半脒对兔肾细胞中兔脑胞内原虫的50%抑制浓度。在该检测系统中，伊曲康唑、托曲珠利、甲硝唑、罗硝唑和更昔洛韦无效。
