1996 - 1997年美国流感嗜血杆菌分离株的大环内酯类药物敏感性及β-内酰胺酶产生情况
Macrolide susceptibility and beta-lactamase production among haemophilus influenzae isolates in the United States, 1996-1997.
作者信息
Hogan P A, Sheehan D J
机构信息
U.S. Pharmaceuticals Group, Pfizer Inc., New York, New York 10017, USA.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3313-4. doi: 10.1128/AAC.42.12.3313.
Abstract
In 1996 and 1997, 68 hospital laboratories throughout the United States determined the beta-lactamase production and susceptibility to macrolides of 1,998 isolates of Haemophilus influenzae obtained from patients with community-acquired respiratory tract infections. The MICs at which 90% of the isolates are inhibited of azithromycin, erythromycin, and clarithromycin were 4, 8, and 16 microgram/ml, respectively. By National Committee for Clinical Laboratory Standards interpretive criteria, 99 and 78% of the isolates were susceptible to azithromycin and clarithromycin, respectively. The prevalence of beta-lactamase production was 32%.
摘要
1996年和1997年，美国68家医院实验室对从社区获得性呼吸道感染患者中分离出的1998株流感嗜血杆菌进行了β-内酰胺酶产生情况及对大环内酯类药物敏感性的测定。阿奇霉素、红霉素和克拉霉素抑制90%分离株的最低抑菌浓度（MIC）分别为4、8和16微克/毫升。按照美国国家临床实验室标准委员会的解释标准，分别有99%和78%的分离株对阿奇霉素和克拉霉素敏感。β-内酰胺酶产生率为32%。
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