膜活性肽对革兰氏阳性和革兰氏阴性需氧菌的体外活性。
In vitro activities of membrane-active peptides against gram-positive and gram-negative aerobic bacteria.
作者信息
Giacometti A, Cirioni O, Greganti G, Quarta M, Scalise G
机构信息
Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3320-4. doi: 10.1128/AAC.42.12.3320.
Abstract
Four peptides, cecropin P1, magainin II, indolicidin, and ranalexin, were evaluated against 202 clinical isolates of gram-positive and gram-negative aerobic bacteria by a microbroth dilution method. The gram-negative isolates were more susceptible to cecropin P1. Ranalexin was the most active compound against the gram-positive strains. The bactericidal activity of each peptide was equivalent to, or 1 dilution above, the MIC. In conclusion, the four peptides exhibited different in vitro activities and rapid time-dependent killing.
摘要
采用微量肉汤稀释法，对天蚕素P1、蛙皮素II、吲哚杀菌素和豹蛙抗菌肽这四种肽针对202株革兰氏阳性和革兰氏阴性需氧菌临床分离株进行了评估。革兰氏阴性分离株对天蚕素P1更敏感。豹蛙抗菌肽是针对革兰氏阳性菌株活性最强的化合物。每种肽的杀菌活性等同于最低抑菌浓度（MIC）或比MIC高1个稀释度。总之，这四种肽表现出不同的体外活性和快速的时间依赖性杀菌作用。
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