曲伐沙星在由对环丙沙星敏感、耐甲氧西林金黄色葡萄球菌引起的实验性心内膜炎中的比较疗效
Comparative efficacy of trovafloxacin in experimental endocarditis caused by ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus.
作者信息
Kim Y S, Liu Q, Chow L L, Chambers H F, Täuber M G
机构信息
Infectious Diseases Laboratory, San Francisco General Hospital, and Departments of Medicine and Neurology, University of California, San Francisco, San Francisco, California 94143-0811, USA.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3325-7. doi: 10.1128/AAC.42.12.3325.
Abstract
The new fluoroquinolone trovafloxacin was tested against a ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus strain in the rabbit model of endocarditis. Trovafloxacin was more effective than vancomycin (CFU/g of vegetation, 2.65 +/- 1.87 versus 4.54 +/- 2.80 [mean +/- standard deviation]; P < 0.05) or ampicillin-sulbactam plus rifampin (4.9 +/- 1.1 CFU/g). The addition of ampicillin-sulbactam to trovafloxacin tended to reduce titers further.
摘要
在兔心内膜炎模型中，对新型氟喹诺酮类药物曲伐沙星与环丙沙星敏感、耐甲氧西林金黄色葡萄球菌菌株进行了测试。曲伐沙星比万古霉素（每克赘生物中的菌落形成单位，2.65±1.87对4.54±2.80[平均值±标准差]；P<0.05）或氨苄西林-舒巴坦加利福平（4.9±1.1菌落形成单位/克）更有效。在曲伐沙星中添加氨苄西林-舒巴坦有进一步降低滴度的趋势。
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