Dogan H N, Rollas S, Erdeniz H
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Marmara University, Istanbul, Turkey.
Farmaco. 1998 Jul 30;53(7):462-7. doi: 10.1016/s0014-827x(98)00049-4.
In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2-naphthoic acid hydrazide were synthesized to screen for their antimicrobial activity. The structures of these substances were elucidated using elemental analysis and UV, 1H NMR, and mass spectral methods. All of these compounds were tested in vitro for their antibacterial and antifungal activity.
在本研究中，合成了一些由3-羟基-2-萘甲酰肼衍生的1,4-二取代硫代氨基脲、1,2,4-三唑和1,3,4-噻二唑类新型化合物，以筛选其抗菌活性。使用元素分析、紫外光谱、1H核磁共振光谱和质谱方法对这些物质的结构进行了阐明。所有这些化合物都在体外测试了其抗菌和抗真菌活性。
