Rebhandl W, Rami B, Turnbull J, Felberbauer F X, Paya K, Bancher-Todesca D, Gherardini R, Mittlboeck M, Horcher E
Division of Paediatric Surgery, University of Vienna Medical School, Austria.
Br J Cancer. 1998 Dec;78(11):1503-6. doi: 10.1038/bjc.1998.713.
Although tissue polypeptide-specific antigen (TPS) has been described as a potentially useful serum marker of tumour activity in adult epithelial tumours, few data are available for childhood malignancies. Neuroblastomas and Wilms' tumours are the commonest types of solid malignancies found in the retroperitoneum of children. At this time, a widely used marker for Wilms' tumour is not available. Using an enzyme-linked immunosorbent assay (ELISA) kit, serum TPS levels in 23 children with neuroblastomas, nine with Wilms' tumours and 22 with benign tumours were evaluated to test the usefulness of the marker in identifying malignancies. Compared with healthy children (n = 110), the preoperative least-square means (LSM) of serum TPS were considerably elevated in both neuroblastoma (LSM = 209 U l(-1)) and Wilms' tumour (LSM = 235 U l(-1)), whereas values in benign tumours were only slightly elevated. Although the Wilms' tumours were associated with higher preoperative serum TPS levels, there was no statistically significant difference compared with neuroblastomas. Receiver operating characteristic analysis (ROC curves) showed a high sensitivity and specificity for both malignancies. Successful treatment resulted in decrease in TPS serum values. Serum TPS measurements in children presenting with abdominal masses can help in diagnosing the two commonest extracranial solid malignancies of childhood. Furthermore, TPS could acquire a pivotal role in monitoring therapy.
尽管组织多肽特异性抗原（TPS）已被描述为成人上皮性肿瘤中肿瘤活性的一种潜在有用的血清标志物，但关于儿童恶性肿瘤的数据却很少。神经母细胞瘤和肾母细胞瘤是儿童腹膜后最常见的实体恶性肿瘤类型。目前，尚无一种广泛应用于肾母细胞瘤的标志物。使用酶联免疫吸附测定（ELISA）试剂盒，对23例神经母细胞瘤患儿、9例肾母细胞瘤患儿和22例良性肿瘤患儿的血清TPS水平进行评估，以检验该标志物在识别恶性肿瘤中的作用。与健康儿童（n = 110）相比，神经母细胞瘤（最小二乘均值[LSM]=209 U l(-1)）和肾母细胞瘤（LSM = 235 U l(-1)）术前血清TPS的LSM均显著升高，而良性肿瘤的值仅略有升高。虽然肾母细胞瘤术前血清TPS水平较高，但与神经母细胞瘤相比无统计学显著差异。受试者操作特征分析（ROC曲线）显示两种恶性肿瘤均具有较高的敏感性和特异性。成功治疗导致TPS血清值下降。对出现腹部肿块的儿童进行血清TPS检测有助于诊断儿童期两种最常见的颅外实体恶性肿瘤。此外，TPS在监测治疗中可能发挥关键作用。
