Polleux F, Giger R J, Ginty D D, Kolodkin A L, Ghosh A
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Science. 1998 Dec 4;282(5395):1904-6. doi: 10.1126/science.282.5395.1904.
Cortical neurons communicate with various cortical and subcortical targets by way of stereotyped axon projections through the white matter. Slice overlay experiments indicate that the initial growth of cortical axons toward the white matter is regulated by a diffusible chemorepulsive signal localized near the marginal zone. Semaphorin III is a major component of this diffusible signal, and cortical neurons transduce this signal by way of the neuropilin-1 receptor. These observations indicate that semaphorin-neuropilin interactions play a critical role in the initial patterning of projections in the developing cortex.
皮质神经元通过白质中刻板的轴突投射与各种皮质和皮质下靶点进行通信。切片重叠实验表明，皮质轴突向白质的初始生长受边缘区附近一种可扩散的化学排斥信号调控。信号素III是这种可扩散信号的主要成分，皮质神经元通过神经纤毛蛋白-1受体转导该信号。这些观察结果表明，信号素-神经纤毛蛋白相互作用在发育中皮质投射的初始模式形成中起关键作用。
