Edström S, Vahlne A
Acta Otolaryngol. 1976 Sep-Oct;82(3-4):212-5. doi: 10.3109/00016487609120886.
The immune system of a case of Cogan's syndrome was investigated. A transient depression of the cell-mediated immunity was found. Thus, during the acute stage of the disease, there was a depression of the cutaneous delayed hypersensitivity reaction to PPD and a decrease in the number of T cells. There were also signs of complement consumption. A possible pathogenesis based on immune complexes due to a preceding viral infection is discussed.
对一例柯根综合征患者的免疫系统进行了研究。发现细胞介导的免疫出现短暂抑制。因此，在疾病的急性期，对结核菌素纯蛋白衍生物（PPD）的皮肤迟发型超敏反应受到抑制，T细胞数量减少。也有补体消耗的迹象。讨论了基于先前病毒感染导致免疫复合物形成的可能发病机制。
