Arnold W, Gebbers J O
Laryngol Rhinol Otol (Stuttg). 1984 Aug;63(8):428-32.
Using the indirect immunofluorescence technique, IgG and IgA antibodies against human cornea and IgG antibodies against human inner ear tissue (stria vascularis, Reissner's membrane, spiral ligament, dark cell area) were demonstrated in the serum of a patient with cogan's syndrome. Sera of controls (healthy individuals) did not show positive reactions. Additionally the serum of two patients suffering from "idiopathic" progressive sensorineural hearing loss contained antibodies (IgG) which reacted with human inner ear tissue only but not with human cornea. A possible autoimmune mechanism in Cogan's syndrome is discussed.
运用间接免疫荧光技术，在一名科根综合征患者的血清中检测到了抗人角膜的IgG和IgA抗体以及抗人内耳组织（血管纹、内耳膜迷路、螺旋韧带、暗细胞区）的IgG抗体。对照组（健康个体）的血清未显示出阳性反应。此外，两名患有“特发性”进行性感音神经性听力损失的患者的血清中含有仅与人内耳组织反应而不与人角膜反应的抗体（IgG）。文中讨论了科根综合征可能的自身免疫机制。
