Gustafson A, Gustafsson B
Acta Med Scand. 1976;200(4):241-8.
Out of 14 cases of poisoning assumed to be due to dextropropoxyphene-containing drugs, propoxyphene and its main metabolite norpropoxyphene could be demonstrated in 11. The concentrations of the drugs were determined shortly after admission and then after 2, 4, 6 and 10 hours (in four cases also after 16 hours). The highest plasma concentration of propoxyphene, 0.74 mug/ml, was found in one case of fatal poisoning. Another patient with a plasma concentration of 0.51 mug/ml showed signs of severe respiratory depression but survived after respirator therapy. In the patients with lower plasma concentrations the poisoning had a benign course. In most cases the plasma concentration of norpropoxyphene exceeded that of propoxyphene even in the first blood sample.
在14例疑似因含右丙氧芬药物中毒的病例中，11例检测出了丙氧芬及其主要代谢产物去甲丙氧芬。入院后不久以及随后的2、4、6和10小时（4例还在16小时后）测定了药物浓度。在1例致命中毒病例中发现丙氧芬的最高血浆浓度为0.74微克/毫升。另1例血浆浓度为0.51微克/毫升的患者出现了严重呼吸抑制症状，但经呼吸机治疗后存活。血浆浓度较低的患者中毒症状呈良性过程。在大多数情况下，即使在第一份血样中，去甲丙氧芬的血浆浓度也超过了丙氧芬。
