Krantz T, Thisted B, Strøm J, Angelo H R, Sørensen M B
Acta Anaesthesiol Scand. 1986 May;30(4):271-6. doi: 10.1111/j.1399-6576.1986.tb02411.x.
Twelve patients with cardiovascular failure because of propoxyphene self-poisoning were treated with dopamine. The patients responded favourably to dopamine infusion (2-17 micrograms/kg/min) with a dose-dependent rise in systolic arterial blood pressure and a fall in central venous pressure and copious urinary output. Side effects during infusion were few, and in periods where dopamine infusion exceeded 10 micrograms/kg/min no tachyarrhythmias were seen. Eleven of the patients were treated on a respirator. Two patients were discharged from the ICU with signs of hypoxic brain damage, one of whom recovered completely after 2 weeks. Serum propoxyphene and norpropoxyphene were measured in nine patients. All but one patient had either propoxyphene or norpropoxyphene concentrations above 3 mumol/l.
12名因丙氧芬自服中毒导致心血管衰竭的患者接受了多巴胺治疗。患者对多巴胺输注（2 - 17微克/千克/分钟）反应良好，收缩动脉血压呈剂量依赖性升高，中心静脉压下降，尿量增多。输注期间副作用很少，在多巴胺输注超过10微克/千克/分钟的时间段内未观察到快速性心律失常。11名患者使用呼吸机治疗。2名患者因缺氧性脑损伤体征从重症监护病房出院，其中1名患者在2周后完全康复。对9名患者测定了血清丙氧芬和去甲丙氧芬。除1名患者外，所有患者的丙氧芬或去甲丙氧芬浓度均高于3微摩尔/升。
