Rössner S, Olsson A G, Orö L
Acta Med Scand. 1976;200(4):269-71. doi: 10.1111/j.0954-6820.1976.tb08230.x.
The lipid-lowering effects of 3 g of the nicotinic acid derivative pentaerythritoltetranicotinate (niceritrol) given either 1 g X 3 or 1.5 g X 2 have been evaluated in 18 subjects with hyperlipoproteinaemia. When 1 g niceritrol was given three times daily, the serum TG concentration fell from 3.14 +/- 0.48 to 1.86 +/- 0.18 mmol/1 (41% reduction) and the serum cholesterol concentration from 282 +/- 9 to 227 +/- 11 mg/100 ml (20% reduction). The same daily dose, given 1.5 g twice, did not significantly lower the serum TG concentration, and serum cholesterol was lowered by only 12%. Niceritrol tablets prepared with a dissolution time of 60 or 90 min had identical lipid-lowering properties. Although patients may find it practical to take niceritrol only twice daily, such a dose regimen has considerably less effect on elevated serum lipids than a thrice-daily regimen.
已对18名高脂蛋白血症患者评估了3克烟酸衍生物季戊四醇四烟酸酯（尼可酯）的降脂效果，给药方式为1克×3次或1.5克×2次。每日3次给予1克尼可酯时，血清甘油三酯（TG）浓度从3.14±0.48降至1.86±0.18毫摩尔/升（降低41%），血清胆固醇浓度从282±9降至227±11毫克/100毫升（降低20%）。每日剂量相同，分两次给予1.5克时，血清TG浓度未显著降低，血清胆固醇仅降低12%。溶出时间为60或90分钟的尼可酯片具有相同的降脂特性。尽管患者可能觉得每日仅服用两次尼可酯很方便，但这种给药方案对升高的血脂的影响远小于每日三次的给药方案。
