Velasco M E, Smith M A, Siedlak S L, Nunomura A, Perry G
Division of Neuropathology, Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA.
Brain Res. 1998 Dec 7;813(2):329-33. doi: 10.1016/s0006-8993(98)01034-8.
In this study, we found that neuropil threads of Alzheimer disease, rather than being continuous filaments along cell processes, show multiple interruptions. They are segmental in nature and therefore appear as striations rather than continuous filaments along the length of the neurite. Neuritic striation is not an artifact of section thickness since the majority of abnormal filament accumulations are extremely short. The dominance of short striations demonstrates that argyrophilic grains, rather than being distinct structures, simply represent a short variant of striation and that longer striations are arbitrarily considered neuropil threads. Ultrastructural examination showed that the intervals between striations lack a cytoskeleton. We suggest that neuritic striations may interrupt the microtubule system functionally blocking fast neuritic transport as well as playing a role in loss of neuronal connectivity.
在本研究中，我们发现阿尔茨海默病的神经纤维丝并非沿细胞突起的连续细丝，而是呈现多处中断。它们本质上是节段性的，因此沿神经突长度方向表现为条纹而非连续细丝。神经突条纹并非切片厚度造成的假象，因为大多数异常细丝堆积非常短。短条纹占主导表明嗜银颗粒并非独特结构，而仅仅代表条纹的短变体，较长的条纹则被随意视为神经纤维丝。超微结构检查显示条纹之间的间隙缺乏细胞骨架。我们认为神经突条纹可能会中断微管系统，在功能上阻断快速的神经突运输，并在神经元连接丧失中发挥作用。
