Karayiannakis A J, Zbar A, Makri G G, Syrigos K, Athanasiadis L, Alexiou D, Bastounis E A
First Department of Surgery, University of Athens, Laikon Hospital, Athens, Greece.
Eur Surg Res. 1998;30(6):409-13. doi: 10.1159/000008606.
The associations between serum beta-endorphin levels and clinical and metabolic variables as well as beta-endorphin changes after surgically induced weight loss were investigated in 43 morbidly obese patients. A significant positive correlation between beta-endorphin and body weight, degree of body weight increase and ACTH was found preoperatively. Only body weight was independently associated with beta-endorphin levels. Twelve months following vertical banded gastroplasty, there was an extensive weight loss in all patients and improvement in their metabolic profile. A significant reduction in beta-endorphin levels which was proportional to the extent of weight loss was also observed.
对43例病态肥胖患者进行了研究，以探讨血清β-内啡肽水平与临床及代谢变量之间的关联，以及手术诱导体重减轻后β-内啡肽的变化。术前发现β-内啡肽与体重、体重增加程度和促肾上腺皮质激素之间存在显著正相关。只有体重与β-内啡肽水平独立相关。垂直束带胃成形术后12个月，所有患者体重均大幅减轻，代谢状况改善。还观察到β-内啡肽水平显著降低，且与体重减轻程度成正比。
