Zabrocka Liolia, Raczynska Sylwia, Goyke Elzbieta, Sledzinski Zbigniew, Swierczynski Julian
Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland.
Obes Res. 2004 Mar;12(3):505-12. doi: 10.1038/oby.2004.57.
To assess the main determinant of serum leptin concentration changes in morbidly obese patients treated by banded vertical gastroplasty.
Serum leptin and insulin concentrations, insulin resistance, BMI, body weight, and body fat mass in 18 obese women and 8 obese men treated by vertical banded gastroplasty were studied. Lean women and men subjects were used as controls.
Before surgery, serum leptin and insulin concentrations and insulin resistance index were significantly higher in morbidly obese patients than in control subjects. BMI, body fat mass, and serum triacylglycerol concentrations were also significantly higher in obese than in lean subjects. All of these parameters gradually decreased during 50 weeks after surgery. Univariate regression analysis displayed significant correlations between the following: serum leptin concentration and BMI (and body fat mass), serum leptin concentration and serum insulin concentration, and serum leptin concentration and insulin resistance index. Multivariate regression analysis indicated that only BMI was independently correlated with the decrease in serum leptin concentration.
Obtained data suggest the following: 1) vertical banded gastroplasty causes reduction of body weight, serum leptin and insulin concentration, insulin resistance, and serum triacylglycerol concentration; and 2) BMI is the main determinant of the circulating leptin concentration in morbidly obese women after anti-obesity surgery.
评估接受垂直束带胃成形术治疗的病态肥胖患者血清瘦素浓度变化的主要决定因素。
对18名接受垂直束带胃成形术治疗的肥胖女性和8名肥胖男性的血清瘦素和胰岛素浓度、胰岛素抵抗、体重指数（BMI）、体重及体脂肪量进行了研究。选取体重正常的女性和男性作为对照。
术前，病态肥胖患者的血清瘦素和胰岛素浓度以及胰岛素抵抗指数显著高于对照对象。肥胖患者的BMI、体脂肪量及血清甘油三酯浓度也显著高于体重正常者。术后50周内，所有这些参数均逐渐下降。单因素回归分析显示以下各项之间存在显著相关性：血清瘦素浓度与BMI（及体脂肪量）、血清瘦素浓度与血清胰岛素浓度、血清瘦素浓度与胰岛素抵抗指数。多因素回归分析表明，只有BMI与血清瘦素浓度的降低独立相关。
所得数据表明：1）垂直束带胃成形术可导致体重、血清瘦素和胰岛素浓度、胰岛素抵抗及血清甘油三酯浓度降低；2）BMI是肥胖症手术后病态肥胖女性循环瘦素浓度的主要决定因素。
