Soli N E, Nafstad I
Acta Vet Scand. 1976;17(3):316-27. doi: 10.1186/BF03547912.
Four cases of experimental copper poisoning in sheep were examined. Light microscopical and ultrastructural alterations of erythrocytes were observed a few hours before a significant haemolysis was evident. Heinz body formation in otherwise unchanged red cells was the first morphological alteration observed. The Heinz bodies were predominantly membrane-attached. During the haemolytic crisis severe erythrocytic distortion, structural membrane alteration and Heinz body-containing ghost cells were observed. Erythrophagocytosis was mainly located to the RE cells of the spleen. Intrafollicular necroses were found in all histological sections from the spleen. Pathological changes in liver and kidney were comparable to those of earlier reports, comprising hepatocellular and renal tubular necrosis.
对4例绵羊实验性铜中毒病例进行了检查。在明显的溶血现象出现前数小时，观察到红细胞的光镜和超微结构改变。在形态未改变的红细胞中出现海因茨小体形成是观察到的首个形态学改变。海因茨小体主要附着于细胞膜。在溶血危象期间，观察到严重的红细胞变形、细胞膜结构改变以及含海因茨小体的影细胞。红细胞吞噬主要发生在脾脏的网状内皮细胞。在脾脏的所有组织学切片中均发现滤泡内坏死。肝脏和肾脏的病理变化与早期报告的相似，包括肝细胞坏死和肾小管坏死。
