Córdoba A, Manrique M, Zozaya E, Martinez Peñuela J, Gomez-Dorronsoro M, Querol I
Service of Pathology, Hospital de Navarra, Pamplona, Spain.
Diagn Cytopathol. 1998 Dec;19(6):455-7. doi: 10.1002/(sici)1097-0339(199812)19:6<455::aid-dc10>3.0.co;2-s.
We report a case of granular-cell tumor (GCT) in the esophagus. This is a rare location for this tumor and only 80 cases have been described. The tumor was diagnosed in a 24-yr-old woman with epigastralgia. Endoscopic examination revealed a submucosal ulcerated lesion. The smears derived from esophageal brushings contained clusters of granular cells. Histologic examination of the endoscopic biopsy provided diagnostic confirmation of GCT. To our knowledge, this is the first reported case of esophageal GCT in which the characteristic tumor cells were seen in the endoscopic brushing material. This case demonstrates that a cytologic diagnosis of GCT is possible if the lesion is ulcerated and/or brushing is subsequent to taking the biopsy. Although rare in the esophagus, GCT should be considered in the differential diagnosis of esophageal neoplasms.
我们报告一例食管颗粒细胞瘤（GCT）。该肿瘤在此部位较为罕见，仅有80例相关病例报道。该肿瘤在一名24岁有上腹部疼痛的女性中被诊断出来。内镜检查发现一个黏膜下溃疡性病变。食管刷检涂片可见颗粒细胞簇。内镜活检的组织学检查确诊为GCT。据我们所知，这是首例在内镜刷检材料中发现特征性肿瘤细胞的食管GCT病例报告。该病例表明，如果病变为溃疡性且/或在活检后进行刷检，GCT的细胞学诊断是可行的。尽管食管GCT罕见，但在食管肿瘤的鉴别诊断中应考虑到该疾病。
